Share Capital Development

Date	Type of Change	Consideration	Change in Shares	Total Shares
Apr-05	Incorporation	£52,000	26,000,000	26,000,000
Oct-05	Placing	£1,000,000	12,000,000	38,000,000
Oct-05	Isua Option	£0	10,000,000	48,000,000
Jan-06	Placing	£200,000	1,000,000	49,000,000
Jun-06	Placing	£461,000	922,000	49,922,000
Aug-06	Placing	£732,300	732,300	50,654,300
Aug-06	Placing	£40,013	36,375	50,690,675
Mar-07	Placing	£7,675,000	7,675,000	58,365,675
May-07	Placing	£20,425,746	13,556,000	71,921,675
Jun-07	Convert Loan Notes	£0	7,500,000	79,421,675
Sep-07	Placing	£28,821,760	18,824,000	98,245,675
Oct-07	Placing	£809,360	572,500	98,818,175
Dec-07	Warrant Exercise	£94,000	470,000	99,288,175
Jan-08	Warrant Exercise	£515,875	337,500	99,625,675
Jan-08	Employee Contract	£0	66,667	99,692,342
Mar-08	Options Exercise	£85,000	1,000,000	100,692,342
Apr-08	Introduction Fee	£0	161,453	100,853,795
May-08	Options Exercise	£52,500	30,000	100,883,795
Aug-08	Options Exercise	£261,000	150,000	101,033,795
Aug-08	Options Exercise	£9,128,125	5,000,000	106,033,795
Sep-08	Warrant Exercise	£20,000	100,000	106,133,795
Sep-08	Warrant Exercise	£50,000	250,000	106,383,795
Oct-08	Warrant Exercise	£30,000	150,000	106,533,795
Oct-08	Warrant Exercise	£500,000	2,500,000	109,033,795
Nov-08	Warrant Exercise	£870,000	500,000	109,533,795
Dec-09	Options Exercise	£87,000	50,000	109,583,795
Apr-10	Options Exercise	£58,950	45,000	109,628,795
May-10	Options Exercise	£163,750	125,000	109,753,795
May-10	Share Issue	£7,901,250	3,500,000	113,235,795
Sep-10	Warrent Exercise	£870,000	500,000	113,735,795